The Effect of Granulocyte Colony Stimulating Factor (G-CSF) on Ischemia/Reperfusion Injury in an Ovarian Torsion Rat Model: A Prospective Randomized Study

نویسندگان

چکیده

Background: Ovarian torsion is an important gynecological emergency and various agents are used in the experimental phase to prevent ovarian injury. The aim of this study was determine effect granulocyte-colony-stimulating factor (G-CSF) use on ischemia/reperfusion injury torsion/detorsion model rat ovary. Methods: Twenty-eight Wistar-albino rats were randomly divided into four groups. first group designated as sham group, applied remaining three third given saline fourth G-CSF before detorsion. total antioxidant oxidant status, oxidative stress index, catalase, malondialdehyde thiol values measured ovaries, after follicles numbers ovary determined by histopathological examination. Results: There no significant difference between groups markers. However, primary secondary follicle significantly higher than other (p < 0.01). Conclusions: Although histopathologically protective terms number follicles, found biochemical markers associated with reperfusion

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ژورنال

عنوان ژورنال: Clinical and Experimental Obstetrics & Gynecology

سال: 2022

ISSN: ['0390-6663', '2709-0094']

DOI: https://doi.org/10.31083/j.ceog4908187